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Key Innovation: The addition of a C18 fatty diacid side chain extends its half-life to approximately 7 days, enabling once-weekly dosing similar to modern GLP-1 receptor agonists
We used 15 N-labeled FOXO4 FHD and p53 TAD with S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioate (MTSL)-labeled Cys46 for the PRE experiments
Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH, et al
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