glp 1 what it is GLP-1? The Hormone Powering Weight Loss Medications – Revolution Health & Wellness Study finds GLP-1 receptor agonists

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Intestinal permeability occurs when holes develop in the intestinal barrier, often due to damage caused by: Adrenal fatigue Alcohol Capsaicin (in spicy peppers) Dental infections Dysbiosis Enzyme deficiencies Food sensitivities Gluten Gut infections Nonsteroidal anti-inflammatory drugs (NSAIDs) Nutrient depletions Psychological stress Small intestinal bacterial overgrowth (SIBO) Sinus infections Strenuous exercise Stress Surgery or trauma Toxins These holes in the intestinal lining allow for toxins and food particles to leak into the bloodstream, and the body labels these molecules as foreign invaders

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It is important to note that the upregulation of IL-33 observed in some GLP-1 studies does not universally guarantee mucosal defense, as IL-33 can also drive potent Th2 inflammatory responses depending on the tissue context (53)