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In a landmark study led by Naktomi et al ., the authors revealed activation of microglia and astrocytes in the cingulate cortex (CC), hippocampus (HIP), amygdala (AMY), thalamus (THA), midbrain (MID), and pons (PON) using positron emission tomography (PET) scans

This step was repeated one additional time before the GLP-1RsemaglutideGs complex was formed by the addition of 10 M semaglutide, 10 g mL 1 Nb35, and 25 mU mL 1 apyrase to the homogenized membrane suspension

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