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The compound is one of the most-studied peptides in preclinical regenerative-research literature, with more than 100 published animal studies covering gastric and intestinal cytoprotection, tendon and ligament repair, angiogenic pathway activity, and central nervous system models

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The recommendation to combine GHK-Cu and retinol is mechanistically rational, but honest framing requires acknowledging that it is based on mechanistic reasoning and tolerability data rather than a direct clinical trial of the combination