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If youre planning to conceive, your prescriber will usually advise stopping it ahead of trying

With this authorization, we are preparing to test, for the first time in humans, whether a one-time, pancreas-targeted gene therapy delivered via a routine endoscopic procedure could provide durable metabolic control by enabling physiologic, nutrient-responsive GLP-1 expression at the source of disease, said Jacques Bergman, MD, PhD, professor of gastrointestinal endoscopy and deputy chair of the department of gastroenterology and hepatology at Amsterdam UMC, and a principal investigator of the upcoming clinical trial

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Starting with a lower dose and gradually increasing over 12 weeks may improve tolerability, though this approach is not evidence-based