Its approval was based on clinical trial results showing that it reduces weight by over 15 percent on average, when used with a healthy lifestyle program. Garvey, who presented at the European Association for the Study of Diabetes in Sweden, added that this amount of weight loss is sufficient to treat or prevent a broad array of obesity complications that impair health and quality of life and is a game-changer in obesity medicine
J Biotechnol 10(261):194206 Szczeklik K, Krzysciak W, Domagala-Rodacka R, Mach P, Darczuk D, Cibor D, Pytko-Polonczyk J, Rodacki T, Owczarek D (2016) Alterations in glutathione peroxidase and superoxide dismutase activities in plasma and saliva in relation to disease activity in patients with Crohns disease
Secondly, it modulates glucagon secretion (the hormone that promotes glucose release by the liver), contributing to better glycemic stability
What Research Says About Combining These Treatments Published trials examining berberine plus GLP-1 agonist co-administration remain limited