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It's a training distribution problem, not a sign that peptides are illegitimate
Moreover, although the surface of HGF II-K1 for c-MET binding is exposed, the binding of another c-MET to HGF II-K1 in such rigid conformation would clash with HGF I bound c-MET II on the stalk region, explaining why rigid HGF II in the 2:2 complex cannot recruit additional c-MET molecule
Abstract The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure
Science 305 : 19721975
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