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Still, they are also a result of mitochondrial dysfunction, which occurs when mitochondria lose the protection of GSH, free radicals attack the mitochondria, and cellular energy decreases.8 Autoimmune conditions like multiple sclerosis, Crohns disease, rheumatoid arthritis, diabetes, Lyme disease, heavy metal load, organotoxins, and more all have mitochondrial dysfunction, low levels of GSH, and profound fatigue

Indeed, hippocampal neurons displayed significant DNA fragmentation (TUNEL + ), and activated caspase-3 when determined by immunohistochemistry (Perkins et al., 2003)

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