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Gill A, Hoogwerf B, Burger J, Bruce S, MacConell L, Yan P, Braun D, Giaconia J, Malone J: Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study

In preclinical models and early human data, it has been hypothesised that the additional glucagon receptor activity may contribute to increased energy expenditure and broader metabolic effects

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Importantly, these improvements occurred alongside significant weight loss in contrast to insulin therapy, which is associated with weight gain