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18 These findings suggest that iron acts not simply as an initiator of ferroptosis but as a local amplification factor, enabling recipient cells to regenerate lipid peroxidation once exposed to an initiating oxidative cue, thereby functioning as a catalytic driver of propagation dynamics
It may stem from an upset stomach caused by dose escalation
The mechanism of action of PDT is the same as that of PBM, which is to produce cytotoxic reactive oxygen species by activating the photosensitizer with specific wavelengths of light, and then destroying the tight junction proteins to increase the permeability of the BBB
This could affect how much drug companies invest in research and development for future new drugs
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