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Lifestyle changes: The patient has participated in a comprehensive weight management program that encourages behavioral modification, reduced-calorie diet, AND increased physical activity with continuing follow-up for at least 6 months prior to using drug therapy
Proanthocyanidins also inhibit the enzyme cyclooxygenase (the same enzyme inhibited by aspirin and other non-steroidal medications)
In addition, Ito et al
Clinical trials discovered that individuals on this drug can shed as much as 20% of their weight
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