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doi: 10.3389/fphys.2025.1497566 Received 17 September 2024 Accepted 22 January 2025 Published 10 February 2025 Volume 16 - 2025 Edited by Hongxiang Hui, Monterey Park, United States Reviewed by Phiwayinkosi V

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Gene expression studies reveal modulation of 408 neuronal genes, including dramatic increases in OPRM1 (opioid receptor, up 1,294%), KCND1 (up 845%), and SLC8A2 (up 737%)