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Stress is known to drive weight gain
The L-cells in the intestinal epithelium express various nutrient-sensing receptors: Dietary fats are particularly potent GLP-1 secretagogues, activating free fatty acid receptors (such as GPR40 and GPR120) on L-cells Proteins and amino acids stimulate GLP-1 through peptide-sensing mechanisms and calcium-sensing receptors Carbohydrates trigger release via glucose transporters and sweet taste receptors expressed on enteroendocrine cells Dietary fibre , particularly soluble fibre, promotes GLP-1 secretion through fermentation products (short-chain fatty acids) produced by gut microbiota The rate and site of nutrient delivery also influences GLP-1 response
Another study integrated transcriptomic analysis to identify a gene signature comprising seven genes (TMCO3, RAP2A, ITGAV, ZFYVE26, CHST9, HMGN4, and KLHL21) that is associated with acylation
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