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Clinical relevance of nose-to-brain delivery and pre-clinical studies Neurodegenerative diseases are one of the leading causes of death worldwide with an increasing prevalence in the aging society [148]

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Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22

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