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Across the study window, for those without a semaglutide/tirzepatide-type weight loss medication prescription, the rate of opioid poisoning per 10,000 patients was 81 at month zero and decreased to 52 at month 24, while for those with a prescription, opioid poisonings were 30 in 10,000 at month zero and 17 in 10,000 at month 24

For procedures involving sedation or general anesthesia , standard ASA fasting guidelines generally apply for most patients: Clear liquids are allowed up to 2 hours before sedation Light meals should be avoided for at least 6 hours before the procedure For patients identified as higher risk (those with active GI symptoms, in dose escalation, on high doses, or with known motility disorders), the anesthesia provider may recommend additional precautions such as: A 24-hour liquid-only diet before the procedure Point-of-care gastric ultrasound assessment where available Airway-protective strategies during sedation Patients should follow their dental provider's specific instructions, which may include: Taking essential medications (such as blood pressure or heart medications) with small sips of water as directed Maintaining adequate hydration with clear liquids up to the allowed time before the procedure Discussing any active GI symptoms with the dental team before sedation Current multi-society guidance does not recommend routinely holding semaglutide before procedures

Z68.30 BMI 30.0-30.9, adult Z68.31 BMI 31.0-31.9, adult Z68.32 BMI 32.0-32.9, adult Z68.33 BMI 33.0-33.9, adult Z68.34 BMI 34.0-34.9, adult Z68.35 BMI 35.0-35.9, adult Z68.36 BMI 36.0-36.9, adult Z68.37 BMI 37.0-37.9, adult Z68.38 BMI 38.0-38.9, adult Z68.39 BMI 39.0-39.9, adult Z68.41 BMI 40.0-44.9, adult Z68.42 BMI 45.0-49.9, adult Z68.43 BMI 50.0-59.9, adult Z68.44 BMI 60.0-69.9, adult Z68.45 BMI 70 or greater, adult Note: For pediatric patients aged 2-19 years, BMI percentiles are used: Z68.51 BMI less than 5th percentile for age Z68.52 BMI 5th percentile to less than 85th percentile for age Z68.53 BMI 85th percentile to less than 95th percentile for age Z68.54 BMI greater than or equal to 95th percentile for age 3