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Needle safety and disposal: Always use a new needle for each injection Never recap needles after usethis increases needlestick injury risk Dispose of used needles immediately in an approved sharps container When your sharps container is three-quarters full, seal it and return it to your pharmacy or local authority collection point Never dispose of needles in household waste or recycling bins Pen disposal: Once empty or after 6 weeks of use, remove the needle and dispose of the pen according to local guidelines

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**When does it start?** Most patients notice nausea beginning 16 hours after injection

In order to verify LrGSTU5 gene function, a constitutive plant expression vector of LrGSTU5 was transferred into tobacco