Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)
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Endocrine Connections, 14(5), e240529
Melanotan II (MT-II) is a synthetic analog of -melanocyte-stimulating hormone (-MSH) studied for skin tanning, erectile function, and appetite suppression