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While the serum concentration of cobalamin is used diagnostically, the reactions catalyzed by cobalamin dependent enzymes occur in the mitochondria, making it difficult to assess the state of cobalamin availability in the patient
In cats, deficiencies are often linked to gastrointestinal disease, especially inflammatory bowel disease and lymphoma
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Inhibition of NNMT has been shown to reduce fat accumulation and increase energy expenditure in preclinical models
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