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First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: safety and pharmacokinetics in healthy volunteers
NICE guidance on obesity management (CG189) and the technology appraisal for semaglutide (TA875) emphasise a structured, multicomponent approach to weight management that includes dietary modification, increased physical activity, and behavioural interventions as first-line strategies
Designed for broader metabolic coverage at a gentler dose
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