tirzepatide jama - In the SURMOUNT-4 trial, 82.5% of adults with obesity regained ≥25% of initial weight lost within one year of withdrawal; most showed reversal of cardiometabolic improvements. https://ja.ma/4qaMLfO A 2025 JAMA Network Open

received research grant support from Akero, Allergan, Altimmune, Bristol Myers Squibb, Boehringer Ingelheim, Boston Pharma, Corcept, Genfit, Gilead, GlaxoSmithKline, Eli Lilly, Madrigal, Merck, Novartis, Novo Nordisk and Takeda and consulted for Boehringer Ingelheim and Intercept Pharmaceuticals

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