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If constipation develops, discuss appropriate laxative options with your healthcare provider

This difference was apparently driven by the increase in scores (indicating disease progression) in the placebo group, which was below but close to the 3.25 threshold on the motor scale that has been considered to be clinically important to the participants in other studies

308 Historically, a natural menopausal transition has been recognized as a life stage marked by gradually decreasing levels of estradiol (E2, the predominant ovarian estrogen) and progesterone accompanied by increasing levels of FSH and LH, beginning in earnest about two years before and stabilizing about two years after the last menstrual period