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Third, the approval of orforglipron signals that non-peptide small molecules can replicate peptide receptor pharmacology, potentially disrupting the peptide therapeutics market for some targets
via integrated multi-omics analyses (Zhao et al., 2025)
The removal triggered a wind-down period during which compounding pharmacies could continue to produce tirzepatide for existing patients but were required to cease new compounding after the period ended
Quick Answer: Most patients require long-term GLP-1 therapy because stopping these medications typically results in weight regain and worsening blood sugar control, as they treat chronic conditions like type 2 diabetes and obesity
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