The effects of apoptosis stimulation were confirmed to occur only in cells expressing GLP-1R in a gain-of-function experiment (Ben et al., 2024)
While mediation analyses suggest that improved glycemic control, weight loss, and reduced blood pressure contribute to these benefits, they likely do not fully explain the observed renoprotection [36,37,38]
Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jdar E, Leiter LA, Lingvay I, Rosenstock J, Seufert J, Warren ML
They bind to receptors on cells and trigger a range of biological effects, from the regeneration of tissue to the production of hormones making them an increasingly important class of drugs