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Eur J Pharmacol 570:212221 Veljaca, M, Krnic, Z and Brajsa, K (2002) The development of PL 14736 for treatment of inflammatory bowel disease

Elevation of intracellular Ca 2+ activates scramblase to ensure PS externalization, opens the Gardos channels, resulting in K + efflux and subsequent cell shrinkage, and mobilizes calpain, leading to cytoskeleton degradation and membrane microvesiculation [78]