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Its copper delivery function is biologically significant because copper is a cofactor for lysyl oxidase (essential for collagen cross-linking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (mitochondrial energy production)
Anal Biochem 72:248254 Chetboun M, Abitbol G, Rozenberg K, Rozenfeld H, Deutsch A, Sampson SR, Rosenzweig T (2012) Maintenance of redox state and pancreatic beta-cell function: role of leptin and adiponectin
TMAO is reported to be involved in vascular calcification and plaque instability, which are the key risk factors for malignant cardiovascular events (25)
128,180 This led to esketamines approval by the US Food and Drug Administration (FDA) in 2019 for use in patients with treatment-resistant depression
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