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Therefore, close monitoring is recommended when oral drugs are co-administered with GLP-1 RAs or a dual GLP-1/GIP RA

Of these, 35 were randomized controlled trials, although only 28 of these trials included a control group during the intervention and follow-up period

With increasing clinical evidence, GLP-1RAs are set to become essential in treating complex and chronic diseases, offering significant health benefits and addressing unmet medical needs, thus enhancing patient quality of life and solidifying their role in future medical advancements

However, preclinical studies of these drugs demonstrate supportive results in rodent and mice models [53,54,55], and we await further clinical trial data with anticipation