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Patients who titrate slowly over 20-24 weeks (versus the standard 12-16 weeks) report significantly fewer GI symptoms
Certain conditions seem to be associated with the development or worsening of restless legs syndrome, including: Iron deficiency (with or without anemia) Kidney failure Diabetes Parkinsons disease Damage to the nerves in the hands or feet (peripheral neuropathy) Rheumatoid arthritis Pregnancy Medications that may aggravate RLS symptoms include: Antinausea drugs, such as prochlorperazine (Compazine) or metoclopramide Antipsychotic drugs, such as haloperidol (Haldol) or phenothiazine derivatives Some cold and allergy medications that contain older antihistamines like diphenhydramine In some cases, the use of antidepressants How Is Restless Legs Syndrome Diagnosed
Direct determination of paracetamol and its metabolites in urine and serum by capillary electrophoresis with ultraviolet and mass spectrometric detection
Given the peptide molecular weight of 5,414.9 Da and 39 amino acid sequence including non-standard residues, mass spectrometry confirmation of the correct molecular species is essential
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