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11.1 Metabolism under toxic doses/overdose conditions As a result of the principal detoxification pathways, UGT and SULT, becoming saturated during an overdose of paracetamol (APAP), drug metabolism shifts to CYP enzymes, which produce an excess of the poisonous metabolite NAPQI
The flagship clinical trial from Dhaliwal et al
428 Peripheral nociceptor terminals respond to noxious stimuli via an array of receptors and ion channels to initiate an action potential
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