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Incretins Introduction Type 2 diabetes may result from a variety of conditions including -cell dysfunction, where insulin is not produced, and/or due to insulin resistance, in both cases leading to hyperglycemia, and complications in both small and large blood vessels (Silberstein, 2013)

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Indeed endocannabinoid signaling through CB1R regulates the activity of dopamine (DA) neurons in the VTA [52], which projects to the nucleus accumbens, a key brain reward region activated by addictive drugs including THC [53, 54]

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