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She was irritable, couldn't sleep, seemed "wired." The Comprehensive Approach: A naturopathic physician identified the root causes and implemented a new protocol: Eliminate: All folic acid sources All cow dairy Reduce: Leucovorin from 5 mg to 1 mg daily Add: Folinic acid lozenge (800 mcg)400 mcg twice daily Hydroxocobalamin lozenge (1,000 mcg)500 mcg twice daily Glutathione lozenge (25 mg)daily Vitamin D3 (2,000 IU)daily Optimize: Natural folate from vegetables, legumes, eggs The Remarkable Results: Within 1 week: Pleasant mood, slept through night, improved eye contact Within 1 month: Began babbling for the first time, pulled to stand Within 3 months: First words spoken, walking independently Within 6 months: Meeting age-appropriate milestones Now at age 4: Latest MRI normal
On multivariate regression analysis, patients who were treated with GLP-1 RA were 86% less likely to develop lymphedema compared to the non-GLP-1 RA cohort (OR 0.14, 95% CI 0.040.32, p 30
The main results of the combinations of PIO with either GLP-1R agonists or SGLT2 inhibitors in patients with T2D and NAFLD are shown in Table I
