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Pterostilbene-mediated Nrf2 activation: mechanistic insights on Keap1: Nrf2 interface
T.VaillancourtC
Data availability The atomic coordinates for PV3-SC8 GPP3+GSH , PV3-SC8 pleconaril+GSH and wt PV2-CP17 have been submitted to the Protein Data Bank under accession codes 8AYX, 8AYY and 8AYZ, respectively
The evaluation of GPx activity, glutathione reductase (GR), SOD, total serum antioxidant status (TAS), MDA and 8-OHdG in ALS patients, found a significant decrease in TAS levels and an increase of 8-OHdG and MDA levels, together with significantly higher oxidized/reduced glutathione (GSSG/GSH) ratio and IL-6 and IL-8 ( Antioxidants and Amyotrophic Lateral Sclerosis The evidence implicates free radicals and OS as factors related to the pathogenesis of ALS
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