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The substantial reduction in systemic inflammation, as indicated by high-sensitivity C-reactive protein (hs-CRP) levels, alongside improvements in overall metabolic health, such as weight loss and glycemic control, represents significant systemic alterations that may indirectly benefit the brain by mitigating chronic inflammatory stimuli and enhancing cerebrovascular health

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Accepted: April 9, 2019

Clinical vigilance is particularly important during the initial weeks of therapy and following dose increases