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Some patients report localized inflammation at injection sites, while others experience systemic reactions such as rashes or flu-like symptoms

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31 Thus GLP-1RA may, via GLP-1 receptor signaling in the hypothalamus, interfere with mRNA transcription, translation or the cleavage of ObRb to soluble leptin receptors and thereby down-regulate the production of soluble leptin receptors

In the SURPASS-2 study, tirzepatide 15 mg resulted in a faster and greater decline in body weight ( 5.5 kg) compared to semaglutide 1.0 mg, more than doubling the proportion of patients achieving at least 10% weight loss (57% vs 24%) [3]