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Both doses were safe and well tolerated, but the high-dose regimen achieved markedly higher plasma concentrations and produced a faster, greater reduction in SOFA scores and inflammatory biomarkers (CRP and procalcitonin), while preventing thrombomodulin elevation (Fowler et al., 2014)

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doi: 10.1371/journal.pone.0157602 234 SripetchwandeeJPipatpiboonNChattipakornNChattipakornS

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It also affects electrophysiological activity, circadian rhythms, and hormonal levels, indicating its broad impact on physiological processes 3

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