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severe or persistent upper abdominal pain should prompt urgent medical assessment [10] [11] Dehydration and acute kidney injury (AKI): gastrointestinal fluid losses can lead to dehydration, which may precipitate AKI, particularly in those with pre-existing renal impairment or those taking nephrotoxic medicines Delayed gastric emptying: this may affect the absorption of orally administered medicines, including contraceptive pills and thyroid replacement therapy [11] Injection site reactions: redness, bruising, or discomfort at the subcutaneous injection site Heart rate changes: increases in resting heart rate have been noted with GLP-1 class agents [14] [15] Hypoglycaemia: particularly if used alongside insulin or sulphonylureas Potential pancreatitis risk: a class concern with GLP-1 receptor agonists
Because these surgeries bypass the part of the gut where absorption happens, the American Society for Metabolic and Bariatric Surgery notes that lifelong injections are often required
The prolonged plasma half-life of hCG relative to LH attributable to the heavily sialylated -subunit makes it a preferred tool for studying sustained LHCGR stimulation versus pulsatile LH receptor engagement in experimental steroidogenesis models
