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Concrete examples of biased agonism that have clearly improved therapeutic outcomes include the development of -arrestinbiased angiotensin II receptor ligands (which showed reduced hypertension-related adverse effects in preclinical models) and carfentanil-class opioid analogs designed to preferentially engage G-protein over arrestin pathways, thereby reducing respiratory depression (Schmid et al., 2017)
Even when these patients followed instructions and consulted their doctor, they came down with serious and even life-threatening medical conditions
Essential role of Helicobacter pylori -glutamyltranspeptidase for the colonization of the gastric mucosa of mice
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