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Gastrointestinal side effects observed under cotadutide effects are similar in quality but more severe than those under GLP-1RA treatment ( Animal data on a GLP-1/GIP/glucagon triple agonist show strong effects on body weight reduction, and glucose- and lipid normalization in rodents
Condensation reaction Dissolve the treated amino acids in an organic solvent (such as DMF), add a condensation agent (such as DIC) and a catalyst (such as HOBt), and stir at room temperature for several hours to days to complete the condensation reaction
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