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Another study shows that JQ1 can inhibit BRD4 expression and ultimately induce ferroptosis through two pathways, either by inhibiting the histone methylase G9a or by activating the histone deacetylase SIRT1, which can recognize the acetylation site and recruit transcriptional factors (Sui et al., 2019)
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
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