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GLP-1 is a peptide hormone consisting of 30 amino acids derived from glucagonogen, which is processed by the differentiation of the glucagonogen gene expressed by intestinal epithelial endocrine L-cells, and has two biologically active forms, GLP-1 (736 amide) and GLP-1 (7-37), and the intestine is the major source of GLP-1 in plasma (Holst, 2007)
The heart rate signal is slightly stronger due to the glucagon component, but the overall picture is not alarming for healthy adults
All doses greater than 15 mg achieved a statistically significant decrease in body weight after 13 weeks, with patients taking 120 mg experiencing a mean 12.2% decrease in body weight, compared with 1.3% for those taking placebo
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