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After 90 days of topical melatonin 5% twice daily combined with sunscreen for 90 days, the MASI decreased by 31% compared with HQ 4% and sunscreen, which achieved a decrease of 37% [69]
The most common side effects are mild nausea, digestive changes, and reduced appetite (which is part of how the medication works)
in some cases, the slowdown in digestion can lead to constipation
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