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GHRH binds to specific receptors on the surface of somatotrophs, triggering a cascade of intracellular signaling events

Some debate exists about long-term use since obesity tends to be chronic, these medications likely need to be continued to maintain weight loss (as stopping leads to regain, based on observations)

Abstract Spatially resolved multimodal data enable the exploration of transcriptional, proteomic and metabolic regulation, yet analytical tools to integrate these spatial omics modalities, particularly spatial metabolomics, remain limited

many, however, stringently captured HF events as secondary endpoints