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BMJ 357 , j2376 (2017)
Patients on Multiple Hepatically Cleared Medications A patient already taking minoxidil, finasteride (CYP3A4 substrate), and a statin (CYP3A4/CYP2C9) has a more crowded hepatic field than someone on minoxidil alone
In summary, the discovery of CYP51A1 as a conserved sterol 14-demethylase involved in cholesterol biosynthesis was achieved through decades of biochemical, genetic, and structural studies across species
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