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The divergent profiles across dual GLP-1/GIP agonists and triple agonists targeting GIP receptor agonist biology underscore that receptor activity ratios, biased signaling, and tissue-level receptor access remain central questions for the field

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Other analysts have cautioned against putting too much stock in the rate of dropouts, arguing that clinical trial designs do not fully reflect how the drug may be used in practice, including more flexible dosing and patient selection