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Driessen JHM, van Onzenoort HAW, Henry RMA, Lalmohamed A, van den Bergh JP, Neef C, et al

Among other important investigations, future research should explore how dietary patterns influence endogenous GLP-1 activity, how best to maintain weight loss after medication discontinuation, and how to scale effective behavioral interventions across diverse populations

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As a result, significant efforts are being made to develop long-acting GLP-1R agonists, through the substitution of a susceptible amino acid in GLP-1 into a mutant to confer resistance to DPP-IV degradation 12 and the significantly prolonging of GLP-1 half-life via the virtue of the neonatal Fc receptor (FcRn) recycling mechanism through binding to IgG-Fc 13 or human serum albumin (HSA) 14