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Vascular endothelial cells demonstrate functional GLP-1 receptors, providing a direct mechanism for the vasodilatory effects observed with GLP-1 agonists [3]

Flushing typically peaks 12 hours post-injection and resolves within 46 hours

Understanding these genetic factors may help provide context for why your endometriosis presentation includes metabolic or weight-related features, and can support more targeted conversations with your provider about whether GLP-1 therapy aligns with your individual biology

The hormone's effects are relatively short-lived in the body, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), with a half-life of approximately 12 minutes