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While anyone can benefit from healthy B12 levels, certain groups are more likely to experience deficiencies and may see greater advantages from supplementation: Vegans and vegetarians: B12 is primarily found in animal products, making supplementation critical for those on plant-based diets

Instead, according to an older article, typical inflammation causes injection site reactions

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Factors that influence this include: Baseline B12 levels Symptoms and severity Absorption issues or medical conditions Diet and lifestyle factors Some people maintain healthy levels with occasional injections, while others require more consistent support