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This niche is often occupied by an expansion of Proteobacteria and Enterobacteriaceae , which exhibit high levels of Pathogen-Associated Molecular Patterns (PAMPs), such as lipopolysaccharide (LPS) and flagellin (Ciesielska et al., 2020
Through enhancing the activity of alpha-ketoglutarate dehydrogenase, a thiamine-dependent enzyme partially responsible for clearing excess glutamate, high-dose thiamine in animals has been shown to reduce glutamate concentrations and reduce oxidative stress
SOD is the main antioxidant enzyme that eliminates the first product of one-electron reduction of molecular oxygen (O 2 - )
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