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Joint pain developing after starting B12 may reflect: Pre-existing musculoskeletal conditions becoming more noticeable Concurrent inflammatory or degenerative joint disease Reactions to excipients in certain formulations The natural course of an underlying condition If you experience persistent or worsening joint symptoms after beginning B12 supplementation, it is advisable to consult your GP or healthcare provider

We also examined the level of immunoprecipitation of D2R (D2R IP) and found no difference between the two groups (t 5 = 0.36, p = NS