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a sudden jump worsens bloating on a drug that already slows gastric emptying

Some institutions now recommend withholding GLP-1RAs for 12 weeks before elective procedures, particularly if the patient is early in treatment or shows symptoms of gastroparesis

Several animals studies have found that GLP-1 agonists can reduce drug and alcohol seeking behavior, but there isnt strong data from human trials: one small trial found that GLP-1 agonists could reduce opioid cravings, for example, while another found they could reduce cravings for alcohol, but only in people who were living with obesity

There are many reasons that people stop these medications, including side effects, lack of medication availability, achievement of targeted weight loss, and insurance difficulties or inability to afford out-of-pocket costs