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6g) and overall inhibited CNO-triggered Ca 2+ elevations by 54% (Fig
17 , 18 These potential side effects should be carefully weighed when selecting the most appropriate treatment strategy for patients with HFpEF and obesity
Clinical Mechanism and Evidence Base for Dual Agonism Tirzepatide activates both GLP-1R (glucagon-like peptide-1 receptor) and GIPR (glucose-dependent insulinotropic polypeptide receptor), creating dual-agonist benefit
This is a decision chart showing the clinical and practical differences
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